Homogeneous rhodium(i)-catalysis in de novo heterocycle syntheses

Homogeneous Catalysis Homogeneous Catalysis

A Universal Isocyanide for Diverse Heterocycle Syntheses

Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.

Programming peptidomimetic syntheses by translating genetic codes designed de novo.

Although the universal genetic code exhibits only minor variations in nature, Francis Crick proposed in 1955 that "the adaptor hypothesis allows one to construct, in theory, codes of bewildering variety." The existing code has been expanded to enable incorporation of a variety of unnatural amino acids at one or two nonadjacent sites within a protein by using nonsense or frameshift suppressor am...

158 Statistical fluctuations, dynamics, and de novo enzyme catalysis.

My talk will describe our recent theoretical developments in methods and models in quantifying protein statistical and dynamical motions and their influence on catalytic performance of de novo enzymes and the possibility of incorporating fluctuations and dynamics into the early stages of enzyme design.

Reaction mechanisms in homogeneous catalysis

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